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AMR remains a critical global health issue, with carbapenemase-producing Klebsiella pneumoniae recognized by WHO as a priority pathogen. These strains lead to serious infections with high mortality, extensive drug resistance, and limited treatment options. The development of new aminoglycosides like plazomicin, and β-lactam/aminoglycoside combinations, offers progress against XDR Enterobacterales. Yet, fast-emerging resistance challenges their effectiveness, highlighting the need to understand resistance mechanisms and impacts.
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In the abstract, please describe in brief the following: What is to be done: purpose and aims; How the research will be carried out: project organisation, time plan and scientific methods; What is important about the planned research. The abstract shall provide a summary of the purpose and implementation of the research. Please use wording to ensure persons with another subject specialisation can understand the information.
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rational β-lactam/aminoglycoside combinations, represents a major advance against extensively drug-resistant (XDR) Enterobacterales. However, rapidly emerging resistancePeter Hansson threatens their durability, underscoring the need to elucidate the mechanisms driving reduced susceptibility and their clinical consequences.Sandra Sander
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